Douglas Lazarus Selected Research

IT-101

1/2016	Preclinical Efficacy of Bevacizumab with CRLX101, an Investigational Nanoparticle-Drug Conjugate, in Treatment of Metastatic Triple-Negative Breast Cancer.
4/2015	CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer.
2/2015	Translational impact of nanoparticle-drug conjugate CRLX101 with or without bevacizumab in advanced ovarian cancer.
9/2013	Correlating preclinical animal studies and human clinical trials of a multifunctional, polymeric nanoparticle.

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Douglas Lazarus Research Topics

Disease

6	Neoplasms (Cancer) 11/2019 - 09/2013
3	Hypoxia (Hypoxemia) 01/2016 - 02/2015
2	Breast Neoplasms (Breast Cancer) 01/2016 - 04/2015
2	Neoplasm Metastasis (Metastasis) 01/2016 - 04/2015
1	Body Weight (Weight, Body) 03/2016
1	Triple Negative Breast Neoplasms 01/2016
1	Ovarian Neoplasms (Ovarian Cancer) 02/2015

Drug/Important Bio-Agent (IBA)

4	Pharmaceutical PreparationsIBA 11/2019 - 02/2015
4	IT-101IBA 01/2016 - 09/2013
3	Bevacizumab (Avastin)FDA Link 01/2016 - 02/2015
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2016 - 02/2015
2	CamptothecinIBA 01/2016 - 04/2015
2	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 04/2015 - 09/2013
1	cabazitaxel FDA Link 11/2019
1	Antineoplastic Agents (Antineoplastics)IBA 11/2019
1	Therapeutic UsesIBA 11/2019
1	hexanoic acid (hexanoate)IBA 11/2019
1	SolutionsIBA 03/2016
1	CytokinesIBA 03/2016
1	Biological ProductsIBA 03/2016
1	Small Interfering RNA (siRNA)IBA 03/2016
1	Angiogenesis InhibitorsIBA 04/2015
1	Transcription Factors (Transcription Factor)IBA 04/2015
1	PlatinumIBA 02/2015

Therapy/Procedure

3	Therapeutics 01/2016 - 02/2015
1	Drug Therapy (Chemotherapy) 01/2016
1	Replantation 04/2015